Center for Hyperbaric Medicine: Research and Education

The professional team of the Center for Hyperbaric Medicine is committed to the safe practice and advancement of knowledge in undersea and hyperbaric medicine, to the education of medical providers of all disciplines that see patients with conditions which may benefit from hyperbaric oxygen therapy, and to informing the public when recognition of emergent conditions and knowledge of resources can enhance personal and public health.

Hyperbaric Chamber Patient Sitting with Mask, Nurse Standing Photo

To that end, our team members publish peer-reviewed journal articles, work with the health care media for public education purposes, give presentations to health care providers, and conduct independent and collaborative research in undersea and hyperbaric medicine. Links are provided below for each of these activities.

Current research projects

Prospective Observational Study of Healing in Radiation Injured Head and Neck Cancer Patients Treated with Hyperbaric Oxygen. This is an ongoing study looking for correlates of good and poor outcome among such variables as radiation dose, years since radiation, age, co-morbid conditions, compliance, and smoking.

Prevalence of Occult and Recognized Hypothyroidism in Head and Neck Radiation Patients. This is an ongoing observational study born of the informal observation that many patients referred to our service for hyperbaric treatment were hypothyroid and untreated for this condition.

Incidence and Etiology of Seizures During Hyperbaric Oxygen Treatment. Seizures can occur during hyperbaric oxygen treatment. Etiologies include the underlying condition being treated, CNS oxygen toxicity, diabetic hypoglycemia, chronic seizure disorder, and possibly CNS reperfusion. This study seeks to determine the overall incidence and relative frequency of each etiology in this practice.

Hyperbaric Chamber Tech Next to Pipes Photo

Prospective Observational Study of Carbon Monoxide Poisoned Patients. Because of cold winters, Minnesota has one of the highest rates of accidental carbon monoxide poisoning in the nation. The sickest of these patients have been treated in our chamber for decades. We have data on more than 600 patients with moderate to severe CO poisoning.

Long Term Mortality Rates in Patients Suffering Moderate to Severe Carbon Monoxide Poisoning. We have previously published data identifying increased risk of death in people with moderate to severe carbon monoxide poisoning having markers of cardiac injury at the time of poisoning. We are following up on this with a new cohort of patients seeking to refine our understanding of this phenomenon.

Hyperbaric Oxygen Therapy for Acute Traumatic Brain Injury.
Dr. Gaylan Rockswold is applying for NINDS funding for a multicenter, randomized, prospective clinical trial evaluating the efficacy of hyperbaric oxygen in the treatment of severe traumatic brain injury. This study will be a clinical outcomes trial, based on the promising results of prior research at HCMC.

Presentations to health care providers

Hyperbaric Chamber Portal View of Patient and Nurse Photo

Members of our professional team are available on request to give presentations on topics such as the following:Physics and Physiology of the Hyperbaric Environment; Emergency Uses of Hyperbaric Oxygen; Hyperbaric Oxygen and Diabetic Limb Salvage; Radiation Injury Treated with Hyperbaric Oxygen; The Role of Hyperbaric Oxygen in Compromised Grafts and Flaps; The Problem Wound; Diagnosis and Treatment of the Injured Sport Diver; Preparation of the Patient for Hyperbaric Treatment.

Peer-reviewed journal articles

Johnson V, Adkinson C, Bowen M, Ortega H. Should children be SCUBA diving? Cerebral arterial gas embolism in a swimming pool. Pediatric Emergency Care, 28(4): 361-362, April 2012.

Tekle WG, Adkinson CD, Chaudhury SA, Jadhav V, Hassan AE, Rodrigues GJ, Qureshi AI. Factors associated with favorable response to hyperbaric oxygen therapy among patients presenting with iatrogenic cerebral arterial gas embolism. Neurocrit Care, 7 March 2012.

Westgard B, Adkinson C. Power in the study of mortality and necrotizing soft tissue infections. Surgical Infection 11(4):403-404, August 2010.

Gosset WA, Rockswold GL, Rockswold SB, Adkinson, CD, Bergman TA, Quickel RR. The safe treatment, monitoring, and management of severe traumatic brain injury patients in a monoplace chamber. Revised and resubmitted to Journal of Undersea and Hyperbaric Medicine, Vol. 37, No 1. pp35-48, 2010.

Flannagan CE, Daramola OO, Maisel RH, Adkinson, C, Odland RM. Surgical Debridement and Adjunctive Hyperbaric Oxygen in Cervical Necrotizing Fasciitis. Otolaryngology-Head and Neck Surgery, Vol 140(5) 730-734, 2009.

Rockswold SB, Rockswold GL, Zavn DA, Zhang X, Cera CE, Bergman TA, Liu J. A prospective, randomized clinical trial to compare the effect of hyperbaric to normobaric hyperoxia on cerebral metabolism, intracranial pressure, and oxygen toxicity in severe traumatic brain injury. J Neurosurgery October 23, 2009.

Thumbigere-Math V, Gopalakrishnan R, Huckabay S, Basu S, Michalowicz BS, Swenson KK, Adkinson C, Basi D. Bisphosphonate-Associated Osteonecrosis of the Jaw: Clinical features, Risk Factors, Management and Treatment Outcomes of 26 patients. J Oral and Maxillofa Surg 67: 1904-1913, 2009.

Rockswold SB, Rockswold GL, Defillo A. Hyperbaric oxygen in traumatic brain injury. Neurol Res, 29(2):162-172, 2007.

Henry C, Satran D, Lindgren B, Adkinson C, Nicholson C, Henry, T. Myocardial Injury and Long-term Mortality Following Moderate to Severe Carbon Monoxide Poisoning. JAMA 295(4): 398-402, 2006.

Satran, D, Henry CR, Adkinson CD, Nicholson CI, Bracha Y, Henry TD. Cardiovascular Manifestations of Moderate to Severe Carbon Monoxide Poisoning. J American College of Cardiology 45(9): 1513-1516, 2005.

Benson J, Adkinson C, Collier R. Hyperbaric oxygen therapy of iatrogenic cerebral arterial gas embolism. Undersea and Hyperbaric Medicine Vol.10 (2): 117-125, 2003.

Chavez JA, Adkinson CD. Adjunctive Hyperbaric Oxygen in Irradiated Patients Requiring Dental Extractions: Outcomes and Complications. J Oral Maxillofac Surg 59:518-522. 2001.

Wolff, RS, Wirtschafter D, Adkinson, C. Ocular quinine toxicity treated with hyperbaric oxygen Undersea Hyperbaric Med 24(2):131-134, 1997.

Zink RS, Adkinson CD, Davies SF. Neurological recovery after prolonged coma from carbon monoxide poisoning. Amer J Emerg Med, 12(5):607-610, 1994.

Armon C, Deschamps C, Adkinson C, Fealey R, Orzulak T. Hyperbaric treatment of cerebral air embolism sustained during mitral valve replacement. Mayo Clinic Proceedings 66:565-571, 1991.

Prewitt ZP, Peltier GL, Adkinson CD. External ear replantation: Case report. J Hyperbaric Medicine 4(3), 1989.

Adkinson CD, Mahoney BD. Air embolism in a post-operative patient. Case Studies in Emerg Med 5(3):4-8, 1989.