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The WHI is one of the largest clinical studies of women and their health.
This 15-year study involves approximately 150,000 postmenopausal women
across the United States. The Berman Center for Outcomes and Clinical
Research is studying 4,800 Minnesota women, between the age of 50 and
79, to see how changes in diet, hormone therapy, vitamin D and calcium
affect cancer, heart disease and hip fractures.
The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack
Trial (ALLHAT) is sponsored by the National Heart, Lung, and Blood Institute
of the National Institutes of Health. This 6-year study will follow more
than 40,000 patients who suffer more than one risk factor for heart disease.
The study will compare the effectiveness of newer antihypertensive drugs
with standard diuretic therapy for reducing the incidence of heart disease.
MMRF’s Berman Center has been awarded a $12.6 million contract from
the National Heart, Lung, and Blood Institute at the National Institutes
of Health to design and perform a historic study that will attempt to
determine the best treatment for prevention of heart disease in persons
with Type 2 diabetes. The Berman Center will oversee one of seven networks
of clinics in the United States and Canada. Enrollment in the study will
begin in late-2000.
CONVINCE - Study to determine if taking blood pressure
medication affects incidence of heart attack and stroke. Principal Investigator:
Richard H. Grimm, Jr., M.D., Ph.D.
LIFE - 4+ year study comparing the effectiveness of
two blood pressure medications inpatients who have a thickening of one
of the chambers of the heart. Principal Investigator: Henry Smith, M.D.
TROPHY - 4 year study looking at preventing or delaying
the onset of hypertension in persons with high-normal blood pressure.
Principal Investigator: Henry Smith, M.D.
TOPIRAMATE - Study to evaluate the effectiveness of
a drug to treat patients with Amyotropic Lateral Sclerosis (ALS). Principal
Investigator: William David, M.D.
CHARM - 1 year study to determine the effectiveness
of a cholesterol lowering medication to increase bone density in post-menopausal
women who have high cholesterol and decreased bone density. Principal
Investigator: Henry Smith, M.D.
The Berman Center activities include carrying out research to evaluate
the effectiveness of alternative and complementary treatments, such as
acupuncture and herbal treatments.
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